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Vaccinia virus is often used in the technique to make


A) Adjuvant.
B) Booster.
C) Antibodies to toxin.
D) Gamma globulin.
E) "Trojan horse" recombinant vaccine.

F) B) and D)
G) A) and E)

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Immunotherapy is the


A) use of antitoxins.
B) use of immune serum globulin.
C) conferring of passive immunity.
D) administering of preformed antibodies.
E) All of the choices are correct.

F) None of the above
G) B) and D)

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Immune sera is produced in horses for all the following except


A) diphtheria.
B) botulism.
C) snake bites.
D) chickenpox.
E) spider bites.

F) A) and B)
G) All of the above

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Monoclonal antibodies


A) originate from a single B cell clone.
B) have a single specificity for antigen.
C) are secreted by hybridomas.
D) are used in immunology lab tests and cancer therapy.
E) All of the choices are correct.

F) A) and E)
G) C) and D)

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Which process involves a more rapid synthesis and greatly increased titer of antibody when the immune system is subsequently exposed to the same antigen?


A) Neutralization
B) Opsonization
C) Complement fixation
D) Agglutination
E) Anamnestic response

F) D) and E)
G) B) and C)

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T cell response to T-cell-dependent antigens requires


A) typically a protein antigen.
B) binding of T cell to a Class II MHC receptor on an antigen-presenting cell.
C) binding of T cell to a site on the antigen.
D) interleukin-1 activating the T helper cell.
E) All of the choices are correct.

F) D) and E)
G) A) and E)

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Variolation involved using


A) dried, ground smallpox scabs.
B) a recombinant carrier with genetic material of the smallpox virus.
C) preparations of human cowpox lesions.
D) antibodies to the smallpox virus.
E) None of the choices are correct.

F) B) and D)
G) A) and D)

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Killed or inactivated vaccines are prepared by


A) removal of virulence genes from the microbe.
B) treatment with formalin, heat, or radiation.
C) passage of the pathogen through unnatural hosts or tissue culture.
D) long-term subculturing of the microbe.
E) All of the choices are correct.

F) A) and B)
G) B) and C)

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Which sequence of events is correct for a specific immune response?


A) Lymphocyte development, presentation of antigens, antibody production, challenge of B cells.
B) Lymphocyte development, challenge of B cells, antibody production, presentation of antigens.
C) Lymphocyte development, presentation of antigens, B cell challenge, antibody production.
D) Antibody production, lymphocyte production, B cell challenge, presentation of antigens.
E) Presentation of antigens, B cell challenge, antibody production, lymphocyte development.

F) B) and C)
G) B) and D)

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All of the following are advantages of attenuated vaccines over inactivated vaccines except


A) they require smaller doses.
B) they require fewer boosters.
C) they confer longer lasting protection.
D) they can be transmitted to other people.
E) they produce infection but not disease.

F) A) and B)
G) All of the above

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Activation of B cells occurs when antigen bonds to B cell surface immunoglobulin receptors.

A) True
B) False

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Lymphocyte maturation involves


A) hormonal signals that initiate development.
B) B cells maturing in bone marrow sites.
C) T cells maturing in the thymus.
D) release of mature lymphocytes to begin migration to various lymphoid organs.
E) all of the choices are correct.

F) C) and D)
G) A) and E)

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Live, attenuated vaccines


A) include the Sabin polio vaccine.
B) include the measles, mumps, rubella vaccine (MMR) .
C) contain viable microbes that can multiply in the person.
D) require smaller doses and fewer boosters compared to inactivated vaccines.
E) All of the choices are correct.

F) B) and D)
G) A) and B)

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Antibody molecules circulate in lymph, blood, and tissue fluids.

A) True
B) False

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Antigens that elicit allergic reactions are called _____.

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The region of each antibody molecule where amino acid composition is very different from one clone of B lymphocytes to another is the


A) variable region.
B) joining region.
C) constant region.
D) light region.
E) hinge region.

F) D) and E)
G) A) and B)

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High titers of specific antibodies are components of


A) specific immune globulin (SIG) .
B) gamma globulin.
C) immune serum globulin (ISG) .
D) attenuated vaccines.
E) toxoids.

F) B) and D)
G) B) and C)

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Human B lymphocytes mature in an intestinal region called the bursa.

A) True
B) False

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The differences in the classes of immunoglobulins are due primarily to variations in the Fc fragment.

A) True
B) False

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The immunoglobulin/s found on the surface of B cells is/are


A) IgM only.
B) IgG only.
C) IgD only.
D) IgM and IgG.
E) IgE and IgA.

F) A) and C)
G) A) and E)

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