Question 1

Which of the following viruses can cause cancer?

Accepted Answer

A)   Rous sarcoma virus
B)   hepatits B
C)   papillomavirus
D)   Epstein-Barr virus
E)   All of the choices are correct.F) All of the above
G) D) and E)

Question 2

MAPK and MEK are intracellular signaling proteins that mediate cell division induced by growth factors. When mutations in the normal MAPK and MEK genes result in an abnormally high level of MAPK and MEK activity and increases in the rate of cell division, then the mutated gene is called a(n)

Accepted Answer

A)   spliceosome.
B)   transposon.
C)   tumor-suppressor gene.
D)   oncogene.
E)   None of the choices are correct.F) B) and E)
G) B) and C)

Question 3

Which of the following is the cancer of epithelial cells?

Accepted Answer

A)   sarcoma
B)   lymphoma
C)   leukemia
D)   carcinoma
E)   myolomaF) C) and D)
G) All of the above

Question 4

All of the following tumor-suppressor genes inhibit cell division EXCEPT

Accepted Answer

A)   BRCA1.
B)   Rb.
C)   NF1.
D)   p16.
E)   Rb and p16.F) A) and B)
G) A) and C)

Question 5

_______ can convert proto-oncogenes into oncogenes.

Accepted Answer

A)   Gene amplifications
B)   Nonsense mutations
C)   Chromosomal translocations
D)   Missense mutations
E)   Retroviral insertionsF) C) and D)
G) B) and C)

Question 6

Sickle-cell anemia is a human disease that occurs as a result of what type of mutation in the b-globin gene?

Accepted Answer

A)   silent
B)   missense
C)   nonsense
D)   frameshift
E)   senseF) B) and E)
G) All of the above

Question 7

All of the following are chemical mutations EXCEPT

Accepted Answer

A)   nitrogen mustard.
B)   X-rays.
C)   ethyl methanesulfonate.
D)   hydroxylamine.
E)   nitrous acid.F) A) and D)
G) None of the above

Question 8

Which of the following cellular proteins is NOT a part of the epidermal growth factor (EGF) /EGF receptor signaling pathway that leads to cell division?

Accepted Answer

A)   GRB2, Sos, and Ras
B)   Raf-1
C)   MAPK
D)   Myc and Fos-Jun
E)   MutSF) D) and E)
G) A) and D) E

Question 9

Should a genetic abnormality arise, ________ prevent a cell from progressing uncontrollably through the cell cycle.

Accepted Answer

A)   cis-acting elements
B)   checkpoint proteins
C)   trans-acting elements
D)   growth factors
E)   Ras'sF) All of the above
G) C) and E)

Question 10

Which of the following statements about methyl-directed mismatch repair systems is FALSE?

Accepted Answer

A)   Methyl-directed mismatch repair systems require the concerted actions of several proteins.
B)   Methyl-directed mismatch repair systems require exonucleases.
C)   Methyl-directed mismatch repair systems are most often used to correct pyrimidine dimers.
D)   Methyl-directed mismatch repair systems exist in all species.
E)   Methyl-directed mismatch repair systems require incorrectly matched base pairs in the DNA.F) A) and B)
G) All of the above

Question 11

Which of the following LEAST belongs with the others?

Accepted Answer

A)   thymine dimer
B)   UvrA protein
C)   direct repair
D)   nucleotide excision repair
E)   UvrC proteinF) All of the above
G) C) and D)

Question 12

A physician discovered a cancerous tumor in the cartilage of a patient. What type of tumor is this?

Accepted Answer

A)   myoloma
B)   retroviral
C)   sarcoma
D)   leukemia
E)   cystF) B) and D)
G) A) and B) C

Question 13

A researcher determined that a strain of E. coli is producing a shortened version of a protein required for glucose metabolism. What type of mutation could be responsible for this shorter than normal protein?

Accepted Answer

A)   nonsense mutation
B)   missense mutation
C)   silent mutation
D)   sense mutation
E)   frameshift mutationF) C) and D)
G) A) and E)

Question 14

What is the function of the MutS protein in methyl-directed mismatch repair?

Accepted Answer

A)   To excise the mismatched basepair.
B)   To find mismatches.
C)   To directly bind the DNA polymerase.
D)   To make a cut in the nonmethylated DNA strand.
E)   To digest the nonmethylated DNA strand.F) C) and D)
G) A) and B) B

Question 15

Which of the following proteins is a transcriptional factor that binds genes and regulates the transcription of genes that promote cell division?

Accepted Answer

A)   GRB2
B)   epidermal growth factor
C)   myc
D)   raf-1
E)   MAPKF) A) and B)
G) C) and E)

Exam 14: Mutation, DNA Repair, and Cancer

Which of the following viruses can cause cancer?

Correct Answer
verified

MAPK and MEK are intracellular signaling proteins that mediate cell division induced by growth factors. When mutations in the normal MAPK and MEK genes result in an abnormally high level of MAPK and MEK activity and increases in the rate of cell division, then the mutated gene is called a(n)

Correct Answer
verified

Which of the following is the cancer of epithelial cells?

Correct Answer
verified

All of the following tumor-suppressor genes inhibit cell division EXCEPT

Correct Answer
verified

_______ can convert proto-oncogenes into oncogenes.

Correct Answer
verified

Sickle-cell anemia is a human disease that occurs as a result of what type of mutation in the b-globin gene?

Correct Answer
verified

All of the following are chemical mutations EXCEPT

Correct Answer
verified

Which of the following cellular proteins is NOT a part of the epidermal growth factor (EGF) /EGF receptor signaling pathway that leads to cell division?

Correct Answer
verified
E

Should a genetic abnormality arise, ________ prevent a cell from progressing uncontrollably through the cell cycle.

Correct Answer
verified

Which of the following statements about methyl-directed mismatch repair systems is FALSE?

Correct Answer
verified

Which of the following LEAST belongs with the others?

Correct Answer
verified

A physician discovered a cancerous tumor in the cartilage of a patient. What type of tumor is this?

Correct Answer
verified
C

A researcher determined that a strain of E. coli is producing a shortened version of a protein required for glucose metabolism. What type of mutation could be responsible for this shorter than normal protein?

Correct Answer
verified

What is the function of the MutS protein in methyl-directed mismatch repair?

Correct Answer
verified
B

Which of the following proteins is a transcriptional factor that binds genes and regulates the transcription of genes that promote cell division?

Correct Answer
verified

Exam 14: Mutation, DNA Repair, and Cancer

Which of the following viruses can cause cancer?

Correct AnswerverifiedShow Answer

MAPK and MEK are intracellular signaling proteins that mediate cell division induced by growth factors. When mutations in the normal MAPK and MEK genes result in an abnormally high level of MAPK and MEK activity and increases in the rate of cell division, then the mutated gene is called a(n)

Correct AnswerverifiedShow Answer

Which of the following is the cancer of epithelial cells?

Correct AnswerverifiedShow Answer

All of the following tumor-suppressor genes inhibit cell division EXCEPT

Correct AnswerverifiedShow Answer

_______ can convert proto-oncogenes into oncogenes.

Correct AnswerverifiedShow Answer

Sickle-cell anemia is a human disease that occurs as a result of what type of mutation in the b-globin gene?

Correct AnswerverifiedShow Answer

All of the following are chemical mutations EXCEPT

Correct AnswerverifiedShow Answer

Which of the following cellular proteins is NOT a part of the epidermal growth factor (EGF) /EGF receptor signaling pathway that leads to cell division?

Correct AnswerverifiedE

Should a genetic abnormality arise, ________ prevent a cell from progressing uncontrollably through the cell cycle.

Correct AnswerverifiedShow Answer

Which of the following statements about methyl-directed mismatch repair systems is FALSE?

Correct AnswerverifiedShow Answer

Which of the following LEAST belongs with the others?

Correct AnswerverifiedShow Answer

A physician discovered a cancerous tumor in the cartilage of a patient. What type of tumor is this?

Correct AnswerverifiedC

A researcher determined that a strain of E. coli is producing a shortened version of a protein required for glucose metabolism. What type of mutation could be responsible for this shorter than normal protein?

Correct AnswerverifiedShow Answer

What is the function of the MutS protein in methyl-directed mismatch repair?

Correct AnswerverifiedB

Which of the following proteins is a transcriptional factor that binds genes and regulates the transcription of genes that promote cell division?

Correct AnswerverifiedShow Answer

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E

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C

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B

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